Bethesda, Maryland, USA: The National Institutes of Health (NIH) has launched the Office of Research Innovation, Validation, and Application (ORIVA) to accelerate the use of human-based research technologies and reduce reliance on animal testing in biomedical research. Announced by NIH Director Jay Bhattacharya, the new office will promote advanced methods such as 3D human tissue models, organoids, and computational tools that more closely reflect human biology.

ORIVA is part of NIH's broader strategy to modernize biomedical research by supporting New Approach Methodologies (NAMs). The initiative aims to expand funding for non-animal research methods, involve experts in alternative technologies during grant reviews, and improve oversight of research spending on both animal and human-based studies.

The move reflects a growing shift toward innovative research approaches, including artificial intelligence, organ-on-a-chip systems, and advanced computational modeling. While animal testing has contributed significantly to scientific discoveries, NIH believes newer human-centered technologies could improve the accuracy of research findings and help accelerate the development of treatments for diseases such as cancer and Alzheimer's.